Detailed Scientific Program

We are delighted to present the program of AMP Europe 2018!
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Monday, April 30

9:00 AM – 9:15 AM    Opening Remarks
9:15 AM – 10:45 AM Emerging Knowledge:
Recent Advances in Liquid Biopsies: Challenges and Solutions 
Moderators: Andrea Ferreira-Gonzalez (Richmond, USA) and Ernst-Jan Speel (Maastricht, The Netherlands)
9:15 AM 10:00 AM CANCER-ID: European Network for Validation of Liquid Biopsy Tests
Klaus Pantel (Hamburg, Germany) 
 
10:00 AM 10:45 AM Personalized Liquid Biopsy: Applications in Colorectal, Bladder, Breast, Lung and Beyond
C. Jimmy Lin (San Carlos, USA)
 
11:00 AM – 12:00 PM Innovation Lab: Quality Control and Assessment in Cancer Diagnostics
Moderator: Rami Mahfouz (Beirut, Lebanon)
11:00 AM – 11:30 AM The Role of Reference Materials for Improving Quality of Cancer Diagnostics
Sandi Deans (Sheffield, UK)
 
11:30 AM – 12:00 PM Improving the Proficiency of Molecular Diagnostics by External Quality Assessment (EQA)
Michael Neumaier (Heidelberg, Germany)
12:15 PM – 1:15 PM Industry Symposium >>  
1:15 PM – 2:15 PM Lunch Break  
2:15 PM – 3:15 PM Abstract Session: Oral presentations from selected abstracts 
2:15 PM – 2:30 PM Comprehensive Molecular Characterization of Metastatic Cancer Using Whole-Genome
Sequencing – a Dutch National Initiative
Paul Roepman (Amsterdam, The Netherlands)
2:30 PM – 2:45 PM Multitumor Profiling of Lymphocyte Activation Gene 3 (LAG-3) and Association with Immune Cell Phenotypes
R. Edwards (Princeton, USA)
2:45 PM – 3:00 PM Exploratory Analysis of Janus Kinase 1 (JAK1) Loss-of-Function (LoF) Mutations in Patients With DNA Mismatch
Repair-Defi cient/Microsatellite Instability-High (dMMR/MSI-H) Metastatic Colorectal Cancer (mCRC) Treated With
Nivolumab + Ipilimumab in CheckMate-142
Scott Kopetz (Houston, USA)
3:00 PM – 3:15 PM QIAseq Digital Sequencing and Biomedical Genomics Workbench: Application to Liquid Biopsy in Bladder Cancer
Francesco Lescai (Aarhus, Denmark)
3:30 PM – 4:30 PM Industry Symposium >>
 
4:30 PM – 5:15 PM Coffee Break: Visit Posters   
5:15 PM – 6:15 PM Emerging Knowledge: CRISPR 
Moderators: Andrea Ferreira-Gonzalez (Richmond, USA) and Ernst-Jan Speel (Maastricht, The Netherlands)
5:15 PM – 6:15 PM Harnessing RNA Targeting CRISPR Systems for Transcriptome Engineering and Human Health
Omar Abudayyeh (Cambridge, USA)
 
6:15 PM – 7:15 PM Get Together in the Exhibition Hall  

Tuesday, May 1

8:00 AM –  9:30 AM Emerging Knowledge: Biological Themes Across Tumor Types 
Moderators: Winand Dinjens (Rotterdam, The Netherlands) and Ernst-Jan Speel (Maastricht, The Netherlands)
 8:00 AM – 8:45 AM New Insights in the Pathogenesis of MSI Cancers
Aysel Ahadova (Heidelberg, Germany)
8:45 AM – 9:30 AM Next Generation Pathology Molecular Diagnostics: Combining DNA and RNA Analysis for Treatment
Rene Bernards (Amsterdam, The Netherlands)
9:30 AM – 10:15 AM Coffee Break: Visit Posters and Exhibit (Odd-numbered Posters Attended)
10:15 AM – 11:15 AM Industry Symposium >>
11:30 AM – 1:00 PM Innovation Lab: Tumor Mutational Burden 
Moderators: Winand Dinjens (Rotterdam, The Netherlands) and Albrecht Stenzinger (Heidelberg, Germany)
 11:30 AM– 12:15 PM Microsatellite Instability in Relation to PDL1 Expression and Tumor Mutational Burden in Cancer Patients
Ari M. VanderWalde (Germantown, USA)
12:15 PM– 1:00 PM Novel mRNA Vaccines for Personalized Cancer Immunotherapy
Alina Klein (Mainz, Germany)
1:00 PM – 2:00 PM Lunch Break
2:00 PM – 3:00 PM Industry Symposium >>
3:15 PM – 4:15 PM Abstract Session: Oral Presentations of selected abstracts 
3:15 PM– 3:30 PM Assessment of Circulating Tumor DNA in Patients with Metastatic Colorectal Cancer Treated with Cetuximab Monotherapy
Lindsay Angus (Rotterdam, Netherlands)
3:30 PM– 3:45 PM External Quality Assessment Schemes for Gene Mutation Testing in Oncology: Comparison of Performance between FFPE-Tissue and ctDNA in Plasma
Kaat Van Casteren (Leuven, Belgium)
3:45 PM– 4:00 PM Development and Characterization of Multigene Molecular Cytopathology Cell Slides as a Potential Fine Needle Aspirate (FNA)-Mimetic Specimen for Profi ciency Testing
Sonika Saddar (Milpitas, USA)
4:00 PM– 1:00 PM Use of Highly Multiplexed Reference Materials to Facilitate Validation of a Clinical NGS Tumor Fusion RNA Assay
Dan Brudzewsky (Gaithersburg, USA)
4:15 PM – 5:15 PM Innovation Lab: Single Cell Sequencing
Moderators: Rami Mahfouz (Beirut, Lebanon) and Albrecht Stenzinger (Heidelberg, Germany)
4:15 PM – 5:15 PM Simultaneous Analysis of Cancer Clones and Immune Microenvironments Through Single Cell RNA Sequencing
Trevor Pugh (Toronto, Canada)
5:15 PM – 6:15 PM Innovation Lab: AMP NGS Guidelines
Andrea Ferreira-Gonzalez (Richmond, USA)
Albrecht Stenzinger (Heidelberg, Germany)
5:15 PM – 6:15 PM Practice Guidelines for Validation, Interpretation
and Reporting of NGS-Based Oncology Tests
Marina N. Nikiforova (Pittsburgh, USA)

Wednesday, May 2

8:00 AM – 9:30 AM Emerging Knowledge: Immunotherapies 
Moderator: Albrecht Stenzinger (Heidelberg, Germany)
8:00 AM – 8:45 AM Immunotherapies in Cancer, 21st Century Vaccines
Carl Figdor (Nijmegen, The Netherlands)
8:45 AM – 9:30 AM Tumor Mutational Burden-MSI
Hugo Horlings (Amsterdam, The Netherlands)
9:30 AM – 10:15 AM Coffee Break: Visit Posters and Exhibit (Even-numbered Posters Attended)
10:15 AM – 11:15 AM Industry Symposium >>
11:30 AM – 1:00 PM Innovation Lab: Battle of the Bioinformatics Pipeline   
Moderators: Winand Dinjens (Rotterdam, The Netherlands) and Albrecht Stenzinger (Heidelberg, Germany)
Agilent Technologies
Elias Hage (Amstelveen, The Netherlands)
Qiagen
Tim Bonnert (Manchester, UK)
Thermo Fisher Scientific
Greg Tyrelle (The Hague, The Netherlands)
1:00 PM – 2:00 PM Lunch Break  
2:00 PM – 3:00 PM Industry Symposium >>
 
3:15 PM – 4:45 PM Emerging Knowledge: Clinically Significant Big Data  
Moderator: Laura Tafe (Lebanon, USA)
3:15 PM – 4:00 PM Turning Little Data into Big Data: Data Science and the Omics
Mark Hoffman (Missouri, USA)
4:00 PM – 4:45 PM Oncology Research Information Exchange Network (ORIEN)
William S. Dalton (Tampa, USA)
4:45 PM – 5:00 PM Award Recognition & Closing Remarks

 

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